An Overall Review of The Platelet Rich Plasma (PRP) For Its Users

PRP or Platelet Rich Plasma has become very popular in different medical fields. It has recently been used a lot in the dentistry field. Apart from this, it has also been useful in different applications like tissue regeneration, healing wounds, skin rejuvenating, sports injuries and many more. In this review, we are going to understand more about this PRP, its history, biology, mechanism of action and classification.

History

PRP is also called platelet-rich growth factors, platelet-rich fibrin matrix, PRF and platelet concentrate. This started in the field of haematology in the year the 1970s. it is described as plasma with a platelet count more than the peripheral blood. This was earlier found useful for patients with thrombocytopenia.

Now after 10 years, it has been started to use in maxillofacial surgery as a PRF. PRP also has been predominantly used in the sportsperson and in other fields like cardiac surgery, paediatric surgery, gynaecology, urology, plastic surgery and many more.

If you want to buy these PRP tubes from Germany then you can contact Dr Akhmerov’sPlasmolifting Technologies. They have delivered these tubes to more than 6,00000 doctors. But for a place like Switzerland, you would need a distributor to buy this product.

Biology

Platelets are derived from the bone marrow. They are nucleated, discoid cellular elements which are found in different sizes. Their main function is to provide homeostasis. However, in the recent years, it has been seen that platelets contain a huge number of GFs, and cytokines that can affect inflammation, angiogenesis, cell proliferation and stem cell migration.

PRP is that natural process through which the platelets are activated and the P-granules are degranulated which releases a good number of GFs and cytokines that are important for modification of the Pericellular microenvironment.

Definition of PRP

PRP is a portion of the plasma fraction of autologous blood which has a blood concentration level above the baseline. It has the highest level of PRP present in it and has other clotting factors. Apart from this, it has the GF, chemokines, cytokines and other plasma proteins.

This PRP is obtained from the blood of the patients which then goes through the centrifugation process where the separation of blood contents is done like the red blood cells, PRP, and platelet-poor plasma.

Apart from the plasma, it is also checked for the different parameters like the presence of leukocytes and the activation. This will tell you the type of PRP used in different pathologies.

Mechanism of action

The GFs and the bioactive molecules that are there in the PRP will perform different actions like proliferation, migration, cell differentiation and angiogenesis. The various cytokines and the GFs help in the regulation of hair morphogenesis and the cycle of hair growth.

Devices Used

There are 2 techniques used for obtaining PRP:

  1. Open technique: Here the product is totally exposed to the environment which will come in contact with different materials for products like the pipettes and the product-collection tubes.
  2. Closed technique: here commercial devices are used with CE marking and the product is not exposed to the external environment.

To conclude, PRP is a new therapeutic option that is proven useful in different areas like dermatology, trichology, wound healing etc.

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